4CYG

The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation

Summary for 4CYG

• Entry DOI: 10.2210/pdb4cyg/pdb
• Related: 4CYF 4CYU
• Descriptor: PANTETHEINASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2R)-2,4-dihydroxy-N-[(3S)-3-hydroxy-4-phenylbutyl]-3,3-dimethylbutanamide, ... (6 entities in total)
• Functional Keywords: hydrolase, inflammation, colitis, coa biosynthesis, oxidative stress
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 115205.08

Authors

Boersma, Y.L.,Newman, J.,Adams, T.E.,Sparrow, L.,Cowieson, N.,Lucent, D.,Krippner, G.,Bozaoglu, K.,Peat, T.S. (deposition date: 2014-04-11, release date: 2014-12-10, Last modification date: 2023-12-20)

• Primary citation: Boersma, Y.L.,Newman, J.,Adams, T.E.,Cowieson, N.,Krippner, G.,Bozaoglu, K.,Peat, T.S.; The Structure of Vanin-1: A Key Enzyme Linking Metabolic Disease and Inflammation; Acta Crystallogr.,Sect.D, 70:3320-, 2014; PubMed: 25478849; DOI: 10.1107/S1399004714022767

Experimental method

X-RAY DIFFRACTION (2.3 Å)