4CNC

Crystal structure of human 5T4 (Wnt-activated inhibitory factor 1, Trophoblast glycoprotein)

Summary for 4CNC

• Entry DOI: 10.2210/pdb4cnc/pdb
• Related: 4CNM
• Descriptor: TROPHOBLAST GLYCOPROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: cell adhesion, waif1, tpbg, trovax, cancer, signaling, leucine-rich repeats, wnt/beta-catenin signaling pathway
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 70045.47

Authors

Zhao, Y.,Malinauskas, T.,Harlos, K.,Jones, E.Y. (deposition date: 2014-01-21, release date: 2014-02-26, Last modification date: 2020-07-29)

• Primary citation: Zhao, Y.,Malinauskas, T.,Harlos, K.,Jones, E.Y.; Structural Insights Into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1.; Structure, 22:612-, 2014; PubMed: 24582434; DOI: 10.1016/J.STR.2014.01.009

Experimental method

X-RAY DIFFRACTION (1.77 Å)