4CNC
Crystal structure of human 5T4 (Wnt-activated inhibitory factor 1, Trophoblast glycoprotein)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | TROPHOBLAST GLYCOPROTEIN | polymer | 299 | 32900.4 | 2 | UniProt (Q13641) Pfam (PF01462) Pfam (PF13855) Pfam (PF01463) | HOMO SAPIENS (HUMAN) | 5T4 ONCOFETAL ANTIGEN, 5T4 ONCOFETAL TROPHOBLAST GLYCOPROTEIN, 5T4 ONCOTROPHOBLAST GLYCOPROTEIN, M6P1,5T4, WNT-ACTIVATED INHIBITORY FACTOR 1 |
| 2 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E, F, G, H, S... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 4 | I, U, V, W (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 5 | J, X, Y (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | AA, BA, CA, DA, EA... (B, A) | SULFATE ION | non-polymer | 96.1 | 14 | Chemie (SO4) | |||
| 7 | FA (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | GA, HA (A, B) | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A, B: 60 - 345 (UniProt: Q13641)
| PDB | External Database | Details |
|---|---|---|
| Glu 57 | - | expression tag |
| Thr 58 | - | expression tag |
| Gly 59 | - | expression tag |
| Gly 346 | - | expression tag |
| Thr 347 | - | expression tag |
| Glu 348 | - | expression tag |
| Thr 349 | - | expression tag |
| Ser 350 | - | expression tag |
| Gln 351 | - | expression tag |
| Val 352 | - | expression tag |
| Ala 353 | - | expression tag |
| Pro 354 | - | expression tag |
| Ala 355 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65800.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 3395.9 | |
| All* | Total formula weight | 70045.5 |
