4CIN

Complex of Bcl-xL with its BH3 domain

Summary for 4CIN

• Entry DOI: 10.2210/pdb4cin/pdb
• Related: 4CIM
• Descriptor: BCL-2-LIKE PROTEIN 1, CALCIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: apoptosis
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 Q07817
• Total number of polymer chains: 4
• Total formula weight: 42357.50

Authors

Colman, P.M.,Lee, E.F.,Fairlie, W.D. (deposition date: 2013-12-12, release date: 2014-11-12, Last modification date: 2023-12-20)

• Primary citation: Lee, E.F.,Dewson, G.,Evangelista, M.,Pettikiriarachchi, A.,Zhu, H.,Colman, P.M.,Fairlie, W.D.; The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains; J.Biol.Chem., 289:36001-, 2014; PubMed: 25371206; DOI: 10.1074/JBC.M114.610758

Experimental method

X-RAY DIFFRACTION (2.693 Å)