4CC9

Crystal structure of human SAMHD1 (amino acid residues 582-626) bound to Vpx isolated from sooty mangabey and human DCAF1 (amino acid residues 1058-1396)

Summary for 4CC9

Entry DOI	10.2210/pdb4cc9/pdb
Descriptor	PROTEIN VPRBP, PROTEIN VPX, DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1, ... (6 entities in total)
Functional Keywords	protein binding, hiv, siv, retroviral restriction factor, retroviral accessory protein, ubiquitination, proteasomal degradation
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm: Q9Y4B6 Virion: P19508 Nucleus : Q9Y3Z3
Total number of polymer chains	3
Total formula weight	63166.39
Authors	Schwefel, D.,Groom, H.C.T.,Boucherit, V.C.,Christodoulou, E.,Walker, P.A.,Stoye, J.P.,Bishop, K.N.,Taylor, I.A. (deposition date: 2013-10-19, release date: 2013-12-11, Last modification date: 2018-01-24)
Primary citation	Schwefel, D.,Groom, H.C.T.,Boucherit, V.C.,Christodoulou, E.,Walker, P.A.,Stoye, J.P.,Bishop, K.N.,Taylor, I.A. Structural Basis of Lentiviral Subversion of a Cellular Protein Degradation Pathway. Nature, 505:234-, 2014 Cited by PubMed: 24336198 DOI: 10.1038/NATURE12815 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.473 Å)

Structure validation