4CC9
Crystal structure of human SAMHD1 (amino acid residues 582-626) bound to Vpx isolated from sooty mangabey and human DCAF1 (amino acid residues 1058-1396)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTEIN VPRBP | polymer | 361 | 41073.1 | 1 | UniProt (Q9Y4B6) | HOMO SAPIENS (HUMAN) | DDB1- AND CUL4-ASSOCIATED FACTOR 1, HIV-1 VPR-BINDING PROTE IN, VPRBP, VPR-INTERACTING PROTEIN, DCAF1 |
| 2 | B (B) | PROTEIN VPX | polymer | 119 | 13587.4 | 1 | UniProt (P19508) Pfam (PF00522) | SIMIAN IMMUNODEFICIENCY VIRUS | VIRAL PROTEIN X, X ORF PROTEIN, VPX |
| 3 | C (C) | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 | polymer | 71 | 8052.0 | 1 | UniProt (Q9Y3Z3) | HOMO SAPIENS (HUMAN) | DNTPASE, DENDRITIC CELL-DERIVED IFNG-INDUCED PROTEIN, DCIP, MONOCYTE PROTEIN 5, MOP-5, SAM DOMAIN AND HD DOMAIN-CONTAINING PR OTEIN 1, SAMHD1 |
| 4 | D, E (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 5 | F (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | G, H, I (A, B, C) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 1058 - 1396 (UniProt: Q9Y4B6)
B: 1 - 112 (UniProt: P19508)
C: 582 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 1057 | - | expression tag |
| Glu 1397 | - | expression tag |
| Leu 1398 | - | expression tag |
| Ala 1399 | - | expression tag |
| Leu 1400 | - | expression tag |
| Val 1401 | - | expression tag |
| Pro 1402 | - | expression tag |
| Arg 1403 | - | expression tag |
| Gly 1404 | - | expression tag |
| Ser 1405 | - | expression tag |
| Ser 1406 | - | expression tag |
| Ala 1407 | - | expression tag |
| His 1408 | - | expression tag |
| His 1409 | - | expression tag |
| His 1410 | - | expression tag |
| His 1411 | - | expression tag |
| His 1412 | - | expression tag |
| His 1413 | - | expression tag |
| His 1414 | - | expression tag |
| His 1415 | - | expression tag |
| His 1416 | - | expression tag |
| His 1417 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 556 | - | expression tag |
| Ala 557 | - | expression tag |
| Ser 558 | - | expression tag |
| Trp 559 | - | expression tag |
| Ser 560 | - | expression tag |
| His 561 | - | expression tag |
| Pro 562 | - | expression tag |
| Gln 563 | - | expression tag |
| Phe 564 | - | expression tag |
| Glu 565 | - | expression tag |
| Lys 566 | - | expression tag |
| Gly 567 | - | expression tag |
| Ala 568 | - | expression tag |
| Leu 569 | - | expression tag |
| Glu 570 | - | expression tag |
| Val 571 | - | expression tag |
| Leu 572 | - | expression tag |
| Phe 573 | - | expression tag |
| Gln 574 | - | expression tag |
| Gly 575 | - | expression tag |
| Pro 576 | - | expression tag |
| Gly 577 | - | expression tag |
| Tyr 578 | - | expression tag |
| Gln 579 | - | expression tag |
| Asp 580 | - | expression tag |
| Pro 581 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 62712.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 453.9 | |
| All* | Total formula weight | 63166.4 |
