4CC9
Crystal structure of human SAMHD1 (amino acid residues 582-626) bound to Vpx isolated from sooty mangabey and human DCAF1 (amino acid residues 1058-1396)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016567 | biological_process | protein ubiquitination |
| B | 0005515 | molecular_function | protein binding |
| B | 0019049 | biological_process | virus-mediated perturbation of host defense response |
| B | 0019058 | biological_process | viral life cycle |
| B | 0042025 | cellular_component | host cell nucleus |
| B | 0044423 | cellular_component | virion component |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PG4 A 2393 |
| Chain | Residue |
| A | THR1284 |
| A | HIS1286 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 A 2394 |
| Chain | Residue |
| A | ALA1377 |
| A | LEU1378 |
| B | ARG51 |
| B | ARG70 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1112 |
| Chain | Residue |
| B | CYS89 |
| B | HIS39 |
| B | HIS82 |
| B | CYS87 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | THR592 | |
| B | HIS82 | |
| B | CYS87 | |
| B | CYS89 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS622 |
