4CB7

Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8e)

Summary for 4CB7

Entry DOI	10.2210/pdb4cb7/pdb
Related	4CB4 4CB5 4CB6
Descriptor	POLYMERASE BASIC SUBUNIT 2, GLYCEROL, 5-[2-(2-azanyl-7-methyl-6-oxidanylidene-1H-purin-9-ium-9-yl)ethanoyl]-2-oxidanyl-benzoic acid, ... (4 entities in total)
Functional Keywords	transcription, cap-binding inhibitors
Biological source	INFLUENZA A VIRUS
Total number of polymer chains	2
Total formula weight	37209.08
Authors	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. (deposition date: 2013-10-10, release date: 2013-10-30, Last modification date: 2023-12-20)
Primary citation	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain J.Med.Chem., 56:8915-, 2013 Cited by PubMed: 24134208 DOI: 10.1021/JM401369Y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation