4CB7
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8e)
Summary for 4CB7
Entry DOI | 10.2210/pdb4cb7/pdb |
Related | 4CB4 4CB5 4CB6 |
Descriptor | POLYMERASE BASIC SUBUNIT 2, GLYCEROL, 5-[2-(2-azanyl-7-methyl-6-oxidanylidene-1H-purin-9-ium-9-yl)ethanoyl]-2-oxidanyl-benzoic acid, ... (4 entities in total) |
Functional Keywords | transcription, cap-binding inhibitors |
Biological source | INFLUENZA A VIRUS |
Total number of polymer chains | 2 |
Total formula weight | 37209.08 |
Authors | Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. (deposition date: 2013-10-10, release date: 2013-10-30, Last modification date: 2023-12-20) |
Primary citation | Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain J.Med.Chem., 56:8915-, 2013 Cited by PubMed: 24134208DOI: 10.1021/JM401369Y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report