4BVH
CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND 2'-O-ACETYL-ADP-RIBOSE
Summary for 4BVH
Entry DOI | 10.2210/pdb4bvh/pdb |
Related | 4BUZ 4BV2 4BV3 4BVB 4BVE 4BVF 4BVG |
Descriptor | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, ... (10 entities in total) |
Functional Keywords | hydrolase, inhibitor complex, ex-527 |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion matrix: Q9NTG7 |
Total number of polymer chains | 3 |
Total formula weight | 97653.36 |
Authors | Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-25, release date: 2013-07-17, Last modification date: 2023-12-20) |
Primary citation | Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013 Cited by PubMed: 23840057DOI: 10.1073/PNAS.1303628110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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