4BVH
CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND 2'-O-ACETYL-ADP-RIBOSE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL | polymer | 284 | 31484.2 | 3 | UniProt (Q9NTG7) Pfam (PF02146) | HOMO SAPIENS (HUMAN) | HSIRT3, REGULATORY PROTEIN SIR2 HOMOLOG 3, SIR2-LIKE PROTEIN 3, SIRT3 |
| 2 | D, I, O (A, B, C) | (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide | non-polymer | 248.7 | 3 | Chemie (OCZ) | |||
| 3 | E, P (A, C) | 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 601.4 | 2 | Chemie (OAD) | |||
| 4 | F, M, U (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 5 | G (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | H, N (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | J (B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 1 | Chemie (AR6) | |||
| 8 | K, L, Q, S, T (B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 9 | R (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 10 | V, W, X (A, B, C) | water | water | 18.0 | 488 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94452.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3200.7 | |
| All* | Total formula weight | 97653.4 |
