4BQH

Crystal structure of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei in complex with inhibitor

Summary for 4BQH

Entry DOI	10.2210/pdb4bqh/pdb
Descriptor	UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE, SULFATE ION, (3S)-3-[2-(1,3-benzodioxol-5-yl)-2-oxidanylidene-ethyl]-4-bromanyl-5-methyl-3-oxidanyl-1H-indol-2-one, ... (4 entities in total)
Functional Keywords	transferase, inhibitor
Biological source	TRYPANOSOMA BRUCEI
Total number of polymer chains	1
Total formula weight	61195.09
Authors	Fang, W.,Raimi, O.G.,vanAalten, D.M.F. (deposition date: 2013-05-30, release date: 2013-07-17, Last modification date: 2023-12-20)
Primary citation	Urbaniak, M.D.,Collie, I.T.,Fang, W.,Aristotelous, T.,Eskilsson, S.,Raimi, O.G.,Harrison, J.,Hopkins Navratolova, I.,Frearson, J.A.,Van Aalten, D.M.F.,Ferguson, M.A.J. A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma Brucei. Acs Chem.Biol., 8:1981-, 2013 Cited by PubMed: 23834437 DOI: 10.1021/CB400411X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation