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4BQH

Crystal structure of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003977molecular_functionUDP-N-acetylglucosamine diphosphorylase activity
A0005737cellular_componentcytoplasm
A0006011biological_processUDP-alpha-D-glucose metabolic process
A0006048biological_processUDP-N-acetylglucosamine biosynthetic process
A0016740molecular_functiontransferase activity
A0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
A0016779molecular_functionnucleotidyltransferase activity
A0020015cellular_componentglycosome
A0070569molecular_functionuridylyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1538
ChainResidue
AGLY510
ALEU511
AARG512
AHOH2388
AHOH2389
AHOH2391

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 9VU A 1539
ChainResidue
AHIS49
APHE50
ASER207
AVAL209
AGLY232
AALA236
AALA239
AALA367
AMET370
ALYS371
ATYR376
AHOH2056
AHOH2065
AHOH2315
AGLY44
AVAL45
AASP46

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1540
ChainResidue
AHIS202
AARG245
AHIS263
AHOH2238
AHOH2239
AHOH2409

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PDB entries from 2026-02-04

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