4BPM

Crystal structure of a human integral membrane enzyme

4BPM の概要

• エントリーDOI: 10.2210/pdb4bpm/pdb
• 関連するPDBエントリー: 4BPD
• 分子名称: PROSTAGLANDIN E SYNTHASE, FUSION PEPTIDE, GLUTATHIONE, 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, ... (4 entities in total)
• 機能のキーワード: isomerase, cancer, drug target, in meso crystallization, inflammation, inhibitor, leukotriene c4 synthase, lipid metabolism, membrane-associated proteins in eicosanoid and glutathione metabolism, mapag, membrane protein, mpges1, pain, microcrystal, anomalous dispersion, sulfur-sad, s-sad
• 由来する生物種: HOMO SAPIENS; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21286.73

構造登録者

Li, D.,Wang, M.,Olieric, V.,Caffrey, M. (登録日: 2013-05-27, 公開日: 2014-04-16, 最終更新日: 2019-04-03)

• 主引用文献: Li, D.,Howe, N.,Dukkipati, A.,Shah, S.T.A.,Bax, B.D.,Edge, C.,Bridges, A.,Hardwicke, P.,Singh, O.M.P.,Giblin, G.,Pautsch, A.,Pfau, R.,Schnapp, G.,Wang, M.,Olieric, V.,Caffrey, M.; Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.; Cryst.Growth Des., 14:2034-, 2014; PubMed: 24803849; DOI: 10.1021/CG500157X

実験手法

X-RAY DIFFRACTION (2.08 Å)