4BN5

Structure of human SIRT3 in complex with SRT1720 inhibitor

Summary for 4BN5

• Entry DOI: 10.2210/pdb4bn5/pdb
• Related: 4BN4
• Descriptor: NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-{2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}quinoxaline-2-carboxamide, ... (5 entities in total)
• Functional Keywords: hydrolase, lysine deacetylase, adp ribose
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Mitochondrion matrix: Q9NTG7
• Total number of polymer chains: 12
• Total formula weight: 389773.66

Authors

Nguyen, G.T.T.,Schaefer, S.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-05-13, release date: 2013-06-26, Last modification date: 2023-12-20)

• Primary citation: Nguyen, G.T.T.,Schaefer, S.,Gertz, M.,Weyand, M.,Steegborn, C.; Structures of Human Sirtuin 3 Complexes with Adp-Ribose and with Carba-Nad+ and Srt1720: Binding Details and Inhibition Mechanism; Acta Crystallogr.,Sect.D, 69:1423-, 2013; PubMed: 23897466; DOI: 10.1107/S0907444913015448

Experimental method

X-RAY DIFFRACTION (3.25 Å)