4BN5

Structure of human SIRT3 in complex with SRT1720 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL	polymer	281	31253.0	12	UniProt (Q9NTG7) Pfam (PF02146)	HOMO SAPIENS (HUMAN)	HSIRT3, REGULATORY PROTEIN SIR2 HOMOLOG 3, SIR2-LIKE PROTEIN 3
2	AA, DA, GA, JA, M... (E, F, G, H, A...)	CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		662.5	12	Chemie (CNA)
3	BA, EA, HA, KA, N... (E, F, G, H, A...)	N-{2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}quinoxaline-2-carboxamide	non-polymer		469.6	12	Chemie (SR7)
4	CA, FA, IA, LA, O... (E, F, G, H, A...)	ZINC ION	non-polymer		65.4	12	Chemie (ZN)
5	T, TA, X, XA (C, K, D, L)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	375036.1
Non-Polymers*	Number of molecules	40
	Total formula weight	14737.5
All*	Total formula weight	389773.7

*Water molecules are not included.