4BN4

Structure of human SIRT3 in complex with ADP-ribose

Summary for 4BN4

• Entry DOI: 10.2210/pdb4bn4/pdb
• Related: 4BN5
• Descriptor: NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, ZINC ION, SODIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase, lysine deacetylase, adp ribose
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Mitochondrion matrix: Q9NTG7
• Total number of polymer chains: 1
• Total formula weight: 32428.25

Authors

Nguyen, G.T.T.,Schaefer, S.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-05-13, release date: 2013-06-26, Last modification date: 2023-12-20)

• Primary citation: Nguyen, G.T.T.,Schaefer, S.,Gertz, M.,Weyand, M.,Steegborn, C.; Structures of Human Sirtuin 3 Complexes with Adp-Ribose and with Carba-Nad+ and Srt1720: Binding Details and Inhibition Mechanism; Acta Crystallogr.,Sect.D, 69:1423-, 2013; PubMed: 23897466; DOI: 10.1107/S0907444913015448

Experimental method

X-RAY DIFFRACTION (1.3 Å)