4BKU

Enoyl-ACP reductase FabI from Burkholderia pseudomallei with cofactor NADH and inhibitor PT155

4BKU の概要

• エントリーDOI: 10.2210/pdb4bku/pdb
• 関連するPDBエントリー: 4BKO 4BKQ 4BKR
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 5-(4-amino-2-methylphenoxy)-2-hexyl-4-hydroxy-1-methylpyridinium, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, fatty acid biosynthesis, enoyl- acp reductase, pyridone
• 由来する生物種: BURKHOLDERIA PSEUDOMALLEI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30305.25

構造登録者

Hirschbeck, M.W.,Liu, N.,Neckles, C.,Tonge, P.J.,Kisker, C. (登録日: 2013-04-29, 公開日: 2014-04-09, 最終更新日: 2023-12-20)

• 主引用文献: Schiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C.; Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor.; J.Biol.Chem., 289:15987-, 2014; PubMed: 24739388; DOI: 10.1074/JBC.M113.532804

実験手法

X-RAY DIFFRACTION (1.841 Å)