4BHW

Structural basis for autoinhibition of the acetyltransferase activity of p300

4BHW の概要

• エントリーDOI: 10.2210/pdb4bhw/pdb
• 分子名称: HISTONE ACETYLTRANSFERASE P300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, ... (4 entities in total)
• 機能のキーワード: transferase, bromodomain, phd domain, ring domain, hat domain, enhanceosome
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 136652.84

構造登録者

Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.,Ortega, E.,Panne, D. (登録日: 2013-04-08, 公開日: 2013-08-14, 最終更新日: 2023-12-20)

• 主引用文献: Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.,Ortega, E.,Panne, D.; Structure of the P300 Catalytic Core and Implications for Chromatin Targeting and Hat Regulation; Nat.Struct.Mol.Biol., 20:1040-, 2013; PubMed: 23934153; DOI: 10.1038/NSMB.2642

実験手法

X-RAY DIFFRACTION (2.799 Å)