4AXL

HUMAN CATHEPSIN L APO FORM WITH ZN

Summary for 4AXL

• Entry DOI: 10.2210/pdb4axl/pdb
• Related: 1CJL 1CS8 1ICF 1MHW 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 4AXM
• Descriptor: CATHEPSIN L1, ZINC ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Lysosome: P07711
• Total number of polymer chains: 1
• Total formula weight: 24408.25

Authors

Banner, D.W.,Benz, J. (deposition date: 2012-06-13, release date: 2013-05-08, Last modification date: 2023-12-20)

• Primary citation: Ehmke, V.,Winkler, E.,Banner, D.W.,Haap, W.,Schweizer, W.B.,Rottmann, M.,Kaiser, M.,Freymond, C.,Schirmeister, T.,Diederich, F.; Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-Ray Crystal Structure Analysis with Human Cathepsin L; Chemmedchem, 8:967-, 2013; PubMed: 23658062; DOI: 10.1002/CMDC.201300112

Experimental method

X-RAY DIFFRACTION (1.92 Å)