4AXL
HUMAN CATHEPSIN L APO FORM WITH ZN
Summary for 4AXL
Entry DOI | 10.2210/pdb4axl/pdb |
Related | 1CJL 1CS8 1ICF 1MHW 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 4AXM |
Descriptor | CATHEPSIN L1, ZINC ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 1 |
Total formula weight | 24408.25 |
Authors | Banner, D.W.,Benz, J. (deposition date: 2012-06-13, release date: 2013-05-08, Last modification date: 2023-12-20) |
Primary citation | Ehmke, V.,Winkler, E.,Banner, D.W.,Haap, W.,Schweizer, W.B.,Rottmann, M.,Kaiser, M.,Freymond, C.,Schirmeister, T.,Diederich, F. Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-Ray Crystal Structure Analysis with Human Cathepsin L Chemmedchem, 8:967-, 2013 Cited by PubMed: 23658062DOI: 10.1002/CMDC.201300112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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