4AV1

Crystal structure of the human PARP-1 DNA binding domain in complex with DNA

Summary for 4AV1

• Entry DOI: 10.2210/pdb4av1/pdb
• Related: 1UK0 1UK1 1WOK 2COK 2CR9 2CS2
• Descriptor: POLY [ADP-RIBOSE] POLYMERASE 1, 5'-D(*AP*AP*GP*TP*GP*TP*TP*GP*CP*AP*TP*TP)-3', 5'-D(*TP*AP*AP*TP*GP*CP*AP*AP*CP*AP*CP*TP)-3', ... (5 entities in total)
• Functional Keywords: transferase, parp1, dna-binding domain, dbd, dna repair, cancer, poly- adp(ribosyl)ation
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus: P09874
• Total number of polymer chains: 6
• Total formula weight: 107959.48

Authors

Ali, A.A.E.,Timinszky, G.,Arribas-Bosacoma, R.,Kozlowski, M.,Hassa, P.O.,Hassler, M.,Ladurner, A.G.,Pearl, L.H.,Oliver, A.W. (deposition date: 2012-05-23, release date: 2012-06-13, Last modification date: 2024-05-01)

• Primary citation: Ali, A.A.E.,Timinszky, G.,Arribas-Bosacoma, R.,Kozlowski, M.,Hassa, P.O.,Hassler, M.,Ladurner, A.G.,Pearl, L.H.,Oliver, A.W.; The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks; Nat.Struct.Mol.Biol., 19:685-, 2012; PubMed: 22683995; DOI: 10.1038/NSMB.2335

Experimental method

X-RAY DIFFRACTION (3.1 Å)