4AV1

Crystal structure of the human PARP-1 DNA binding domain in complex with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0008270	molecular_function	zinc ion binding
B	0003677	molecular_function	DNA binding
B	0008270	molecular_function	zinc ion binding
C	0003677	molecular_function	DNA binding
C	0008270	molecular_function	zinc ion binding
D	0003677	molecular_function	DNA binding
D	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1600

Chain	Residue
A	CYS21
A	CYS24
A	HIS53
A	CYS56

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1600

Chain	Residue
B	CYS125
B	CYS128
B	HIS159
B	CYS162

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1600

Chain	Residue
C	CYS24
C	HIS53
C	CYS56
C	CYS21

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1600

Chain	Residue
D	CYS125
D	CYS128
D	HIS159
D	CYS162

---

Functional Information from PROSITE/UniProt

site_id	PS00347
Number of Residues	36
Details	ZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKkCsesIpKdslRmaimvqspmfdgkvph..WYHfsC

Chain	Residue	Details
A	CYS21-CYS56
A	CYS125-CYS162

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00264","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21233213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22582261","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ODA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00264","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21233213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ODC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ODE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AV1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---