4AV1
Crystal structure of the human PARP-1 DNA binding domain in complex with DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | POLY [ADP-RIBOSE] POLYMERASE 1 | polymer | 223 | 25093.8 | 4 | UniProt (P09874) Pfam (PF00645) In PDB | HOMO SAPIENS (HUMAN) | PARP-1, NAD(+) ADP-RIBOSYLTRANSFERASE 1, ADPRT 1, POLY[ADP-RIBOSE] SYNTHASE 1 |
| 2 | X | 5'-D(*AP*AP*GP*TP*GP*TP*TP*GP*CP*AP*TP*TP)-3' | polymer | 12 | 3692.4 | 1 | SYNTHETIC CONSTRUCT | ||
| 3 | Y | 5'-D(*TP*AP*AP*TP*GP*CP*AP*AP*CP*AP*CP*TP)-3' | polymer | 12 | 3630.4 | 1 | SYNTHETIC CONSTRUCT | ||
| 4 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 5 - 202 (UniProt: P09874)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Trp -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| Pro -14 | - | expression tag |
| Gln -13 | - | expression tag |
| Phe -12 | - | expression tag |
| Glu -11 | - | expression tag |
| Lys -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| His 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 107697.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 107959.5 |
