4ASD

Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with SORAFENIB (BAY 43-9006)

Summary for 4ASD

Entry DOI	10.2210/pdb4asd/pdb
Related	1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X 2XIR 4AG8 4AGC 4AGD
Descriptor	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE (3 entities in total)
Functional Keywords	angiogenesis, nucleotide-binding, inhibitor, phosphorylation, receptor, transferase, kdr
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	40723.22
Authors	McTigue, M.,Deng, Y.,Ryan, K.,Brooun, A.,Diehl, W.,Stewart, A. (deposition date: 2012-04-30, release date: 2012-09-26, Last modification date: 2023-12-20)
Primary citation	McTigue, M.,Murray, B.W.,Chen, J.H.,Deng, Y.,Solowiej, J.,Kania, R.S. Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109:18281-, 2012 Cited by PubMed: 22988103 DOI: 10.1073/PNAS.1207759109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation