4ASD
Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with SORAFENIB (BAY 43-9006)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | polymer | 353 | 40258.4 | 1 | UniProt (P35968) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | VEGFR-2,2.7.10.1, FETAL LIVER KINASE 1, FLK-1, KINASE INSERT DOMAIN RECEPTOR, KDR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, CD309 |
2 | A | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE | non-polymer | 464.8 | 1 | Chemie (BAX) | |||
3 | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence modifications
A: 787 - 939 (UniProt: P35968)
A: 990 - 1171 (UniProt: P35968)
PDB | External Database | Details |
---|---|---|
Met 769 | - | expression tag |
Gly 770 | - | expression tag |
Gly 771 | - | expression tag |
His 772 | - | expression tag |
His 773 | - | expression tag |
His 774 | - | expression tag |
His 775 | - | expression tag |
His 776 | - | expression tag |
His 777 | - | expression tag |
Gly 778 | - | expression tag |
Leu 779 | - | expression tag |
Glu 780 | - | expression tag |
Val 781 | - | expression tag |
Leu 782 | - | expression tag |
Phe 783 | - | expression tag |
Gln 784 | - | expression tag |
Gly 785 | - | expression tag |
Pro 786 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Val 990 | Glu 990 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40258.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 464.8 | |
All* | Total formula weight | 40723.2 |