4APP

Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide

Summary for 4APP

Entry DOI	10.2210/pdb4app/pdb
Related	2BVA 2CDZ 2J0I 2X4Z
Descriptor	SERINE/THREONINE-PROTEIN KINASE PAK 4, N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	transferase, protein kinase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	34081.61
Authors	Knighton, D.D.,Deng, Y.L.,Wang, C.,Guo, C.,McAlpine, I.,Zhang, J.,Kephart, S.,Johnson, M.C.,Li, H.,Bouzida, D.,Yang, A.,Dong, L.,Marakovits, J.,Tikhe, J.,Richardson, P.,Guo, L.C.,Kania, R.,Edwards, M.P.,Kraynov, E.,Christensen, J.,Piraino, J.,Lee, J.,Dagostino, E.,Del-Carmen, C.,Smeal, T.,Murray, B.W. (deposition date: 2012-04-04, release date: 2012-06-06, Last modification date: 2019-05-08)
Primary citation	Guo, C.,Mcalpine, I.,Zhang, J.,Knighton, D.D.,Kephart, S.,Johnson, M.C.,Li, H.,Bouzida, D.,Yang, A.,Dong, L.,Marakovits, J.,Tikhe, J.,Richardson, P.,Guo, L.C.,Kania, R.,Edwards, M.P.,Kraynov, E.,Christensen, J.,Piraino, J.,Lee, J.,Dagostino, E.,Del-Carmen, C.,Deng, Y.L.,Smeal, T.,Murray, B.W. Discovery of Pyrroloaminopyrazoles as Novel Pak Inhibitors. J.Med.Chem., 55:4728-, 2012 Cited by PubMed: 22554206 DOI: 10.1021/JM300204J PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation