4AP6

Crystal structure of human POFUT2 E54A mutant in complex with GDP- fucose

Summary for 4AP6

• Entry DOI: 10.2210/pdb4ap6/pdb
• Related: 4AP5
• Descriptor: GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: transferase, gt-b, gt68
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Endoplasmic reticulum (By similarity): Q9Y2G5
• Total number of polymer chains: 4
• Total formula weight: 202042.27

Authors

Chen, C.,Keusch, J.J.,Klein, D.,Hess, D.,Hofsteenge, J.,Gut, H. (deposition date: 2012-03-30, release date: 2012-08-08, Last modification date: 2020-07-29)

• Primary citation: Chen, C.I.,Keusch, J.J.,Klein, D.,Hess, D.,Hofsteenge, J.,Gut, H.; Structure of Human Pofut2: Insights Into Thrombospondin Type 1 Repeat Fold and O-Fucosylation.; Embo J., 31:3183-, 2012; PubMed: 22588082; DOI: 10.1038/EMBOJ.2012.143

Experimental method

X-RAY DIFFRACTION (3.401 Å)