4AP6
Crystal structure of human POFUT2 E54A mutant in complex with GDP- fucose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2 | polymer | 422 | 49554.0 | 4 | UniProt (Q9Y2G5) Pfam (PF10250) | HOMO SAPIENS (HUMAN) | PEPTIDE-O-FUCOSYLTRANSFERASE 2, O-FUCT-2, PROTEIN O-FUCOSYLTRANSFERASE 2 |
| 2 | E, H, M, Q (A, B, C, D) | GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE | non-polymer | 589.3 | 4 | Chemie (GFB) PubChem (135412609) PubChem (135432122) PubChem (135618130) PubChem (135820750) PubChem (135857542) PubChem (136771500) PubChem (137034801) PubChem (137286751) PubChem (154728870) PubChem (135398578) PubChem (135398655) PubChem (135398688) PubChem (135398715) PubChem (135402013) PubChem (135410864) PubChem (135442158) PubChem (135665286) PubChem (135815440) PubChem (135815442) PubChem (135829314) PubChem (136044550) PubChem (162951224) PubChem (136153884) PubChem (136254584) PubChem (136597497) PubChem (136597502) PubChem (136649460) PubChem (136663939) PubChem (137105976) PubChem (137105977) PubChem (137105978) PubChem (137270783) PubChem (138454237) PubChem (171699380) PubChem (169441079) PubChem (171439195) | |||
| 3 | F, I, J, K, N... (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 4 | G, L, P, R (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) PubChem (312) | |||
| 5 | S, T (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 37 - 429 (UniProt: Q9Y2G5)
| PDB | External Database | Details |
|---|---|---|
| Ser 8 | - | expression tag |
| Met 9 | - | expression tag |
| Ala 10 | - | expression tag |
| Ser 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Ser 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Asp 21 | - | expression tag |
| Tyr 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Lys 28 | - | expression tag |
| Leu 29 | - | expression tag |
| Glu 30 | - | expression tag |
| Val 31 | - | expression tag |
| Leu 32 | - | expression tag |
| Phe 33 | - | expression tag |
| Gln 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Pro 36 | - | expression tag |
| Ala 54 | Glu 54 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 198215.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3826.4 | |
| All* | Total formula weight | 202042.3 |
