4ANW
Complexes of PI3Kgamma with isoform selective inhibitors.
Summary for 4ANW
Entry DOI | 10.2210/pdb4anw/pdb |
Related | 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3ZVV 3ZW3 4ANU 4ANV 4ANX |
Descriptor | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION, 3-AMINO-6-{4-CHLORO-3-[(2,3-DIFLUOROPHENYL)SULFAMOYL]PHENYL}-N-METHYLPYRAZINE-2-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 112648.59 |
Authors | Foster, P.G.,Lougheed, J.C. (deposition date: 2012-03-22, release date: 2012-05-09, Last modification date: 2024-05-01) |
Primary citation | Leahy, J.W.,Buhr, C.A.,Johnson, H.W.B.,Kim, B.G.,Baik, T.,Cannoy, J.,Forsyth, T.P.,Jeong, J.W.,Lee, M.S.,Ma, S.,Noson, K.,Wang, L.,Williams, M.,Nuss, J.M.,Brooks, E.,Heald, N.,Holst, C.,Jaeger, C.,Lam, S.,Lougheed, J.C.,Nguyen, L.,Plonowski, A.,Stout, T.,Foster, P.G.,Wu, X.,Yakes, M.F.,Yu, R.,Zhang, W.,Lamb, P.,Raeber, O. The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors J.Med.Chem., 55:5467-, 2012 Cited by PubMed: 22548342DOI: 10.1021/JM300403A PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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