4AKB
Structure of Galactose Binding lectin from Champedak (CGB) with Galactose
Summary for 4AKB
Entry DOI | 10.2210/pdb4akb/pdb |
Related | 4AK4 4AKC 4AKD |
Descriptor | AGGLUTININ ALPHA CHAIN, AGGLUTININ BETA-4 CHAIN, HEXAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | sugar binding protein, lectin |
Biological source | ARTOCARPUS INTEGER More |
Total number of polymer chains | 8 |
Total formula weight | 68106.17 |
Authors | Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. (deposition date: 2012-02-22, release date: 2013-02-27, Last modification date: 2023-12-20) |
Primary citation | Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. Structures and Binding Specificity of Galactose- and Mannose-Binding Lectins from Champedak: Differences from Jackfruit Lectins Acta Crystallogr.,Sect.F, 70:709-, 2014 Cited by PubMed Abstract: Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding. PubMed: 24915077DOI: 10.1107/S2053230X14008966 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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