4AK4

High resolution structure of Galactose Binding lectin from Champedak (CGB)

Summary for 4AK4

Entry DOI	10.2210/pdb4ak4/pdb
Related	4AKB 4AKC 4AKD
Descriptor	AGGLUTININ ALPHA CHAIN, AGGLUTININ BETA-4 CHAIN, HEXAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	sugar binding protein, lectin, plant, mannose
Biological source	ARTOCARPUS INTEGER More
Total number of polymer chains	16
Total formula weight	136485.14
Authors	Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. (deposition date: 2012-02-21, release date: 2013-02-27, Last modification date: 2023-12-20)
Primary citation	Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. Structures and Binding Specificity of Galactose- and Mannose-Binding Lectins from Champedak: Differences from Jackfruit Lectins Acta Crystallogr.,Sect.F, 70:709-, 2014 Cited by PubMed Abstract: Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding. PubMed: 24915077 DOI: 10.1107/S2053230X14008966 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation