4AKD

High resolution structure of Mannose Binding lectin from Champedak (CMB)

Summary for 4AKD

Entry DOI	10.2210/pdb4akd/pdb
Related	4AK4 4AKB 4AKC
Descriptor	MANNOSE-SPECIFIC LECTIN KM+, CADMIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	sugar binding protein
Biological source	ARTOCARPUS INTEGER
Total number of polymer chains	4
Total formula weight	65848.13
Authors	Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. (deposition date: 2012-02-22, release date: 2013-02-27, Last modification date: 2023-12-20)
Primary citation	Gabrielsen, M.,Abdul-Rahman, P.S.,Othman, S.,Hashim, O.H.,Cogdell, R.J. Structures and Binding Specificity of Galactose- and Mannose-Binding Lectins from Champedak: Differences from Jackfruit Lectins Acta Crystallogr.,Sect.F, 70:709-, 2014 Cited by PubMed Abstract: Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding. PubMed: 24915077 DOI: 10.1107/S2053230X14008966 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation