4AEP
HCV-JFH1 NS5B POLYMERASE STRUCTURE AT 1.8 ANGSTROM
Summary for 4AEP
Entry DOI | 10.2210/pdb4aep/pdb |
Related | 2XXD 2XYM 4AEX |
Descriptor | RNA-DIRECTED RNA POLYMERASE, PHOSPHATE ION (3 entities in total) |
Functional Keywords | transferase, hepacivirus, nonstructural proteins, replication, de novo initiation, priming |
Biological source | HEPATITIS C VIRUS (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q99IB8 |
Total number of polymer chains | 1 |
Total formula weight | 64821.09 |
Authors | Caillet-Saguy, C.,Bressanelli, S. (deposition date: 2012-01-12, release date: 2012-05-02, Last modification date: 2023-12-20) |
Primary citation | Scrima, N.,Caillet-Saguy, C.,Ventura, M.,Harrus, D.,Astier-Gin, T.,Bressanelli, S. Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405. J.Virol., 86:7107-, 2012 Cited by PubMed: 22532694DOI: 10.1128/JVI.00459-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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