4ADQ

CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1

Summary for 4ADQ

Entry DOI	10.2210/pdb4adq/pdb
Related	4ADF
Descriptor	SECRETED PROTEIN BARF1, MACROPHAGE COLONY-STIMULATING FACTOR 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	immune system-receptor complex, rtkiii, extracellular, cytokine receptor-cytokine complex, four-helix bundle, glycoprotein, immunoglobulin domain, oncogene, cytokine/signaling, immune system/receptor
Biological source	Human gammaherpesvirus 4 More
Total number of polymer chains	8
Total formula weight	167647.35
Authors	Elegheert, J.,Bracke, N.,Savvides, S.N. (deposition date: 2012-01-02, release date: 2012-08-22, Last modification date: 2023-12-20)
Primary citation	Elegheert, J.,Bracke, N.,Pouliot, P.,Gutsche, I.,Shkumatov, A.V.,Tarbouriech, N.,Verstraete, K.,Bekaert, A.,Burmeister, W.P.,Svergun, D.I.,Lambrecht, B.N.,Vergauwen, B.,Savvides, S.N. Allosteric Competitive Inactivation of Hematopoietic Csf-1 Signaling by the Viral Decoy Receptor Barf1. Nat.Struct.Mol.Biol., 19:938-, 2012 Cited by PubMed: 22902366 DOI: 10.1038/NSMB.2367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.5 Å)

Structure validation