4AD6
Synthesis and SAR of guanine based analogues for HPPK inhibitors
Summary for 4AD6
Entry DOI | 10.2210/pdb4ad6/pdb |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 7-(2-HYDROXYETHYL)-8-MERCAPTOGUANINE (3 entities in total) |
Functional Keywords | transferase, spr |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 2 |
Total formula weight | 37062.68 |
Authors | Chhabra, S.,Peat, T.S.,Swarbrick, J. (deposition date: 2011-12-22, release date: 2013-01-16, Last modification date: 2023-12-20) |
Primary citation | Chhabra, S.,Barlow, N.,Dolezal, O.,Hattarki, M.K.,Newman, J.,Peat, T.S.,Graham, B.,Swarbrick, J.D. Exploring the Chemical Space Around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme Hppk. Plos One, 8:59535-, 2013 Cited by PubMed: 23565155DOI: 10.1371/JOURNAL.PONE.0059535 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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