4AD6

Synthesis and SAR of guanine based analogues for HPPK inhibitors

Summary for 4AD6

Entry DOI	10.2210/pdb4ad6/pdb
Descriptor	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 7-(2-HYDROXYETHYL)-8-MERCAPTOGUANINE (3 entities in total)
Functional Keywords	transferase, spr
Biological source	Staphylococcus aureus
Total number of polymer chains	2
Total formula weight	37062.68
Authors	Chhabra, S.,Peat, T.S.,Swarbrick, J. (deposition date: 2011-12-22, release date: 2013-01-16, Last modification date: 2023-12-20)
Primary citation	Chhabra, S.,Barlow, N.,Dolezal, O.,Hattarki, M.K.,Newman, J.,Peat, T.S.,Graham, B.,Swarbrick, J.D. Exploring the Chemical Space Around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme Hppk. Plos One, 8:59535-, 2013 Cited by PubMed: 23565155 DOI: 10.1371/JOURNAL.PONE.0059535 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation