Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4AD6

Synthesis and SAR of guanine based analogues for HPPK inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0003848molecular_function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A0009396biological_processfolic acid-containing compound biosynthetic process
B0003848molecular_function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
B0009396biological_processfolic acid-containing compound biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GSY B 1159
ChainResidue
APRO109
BHOH2008
BHOH2046
ALYS110
BTHR43
BALA44
BVAL46
BPHE54
BASN56
BASP95
BPHE123

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GSY A 1159
ChainResidue
ATHR43
AALA44
AVAL46
APHE54
AASN56
AASP95
APHE123
AHOH2011
AHOH2063
AHOH2065
BPRO109
BLYS110

Functional Information from PROSITE/UniProt
site_idPS00794
Number of Residues12
DetailsHPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDVDIL
ChainResidueDetails
AARG88-LEU99

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon