4AD0

Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane

4AD0 の概要

• エントリーDOI: 10.2210/pdb4ad0/pdb
• 関連するPDBエントリー: 4ACY 4ACZ 4AD1 4AD2 4AD3 4AD4 4AD5
• 分子名称: ENDO-ALPHA-MANNOSIDASE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: hydrolase, endomannosidase, glycoside hydrolase gh99, cazy, enzyme-carbohydrate interaction, mannose glycosidase inhibition
• 由来する生物種: BACTEROIDES THETAIOTAOMICRON
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 174551.42

構造登録者

Thompson, A.J.,Williams, R.J.,Hakki, Z.,Alonzi, D.S.,Wennekes, T.,Gloster, T.M.,Songsrirote, K.,Thomas-Oates, J.E.,Wrodnigg, T.M.,Spreitz, J.,Stuetz, A.E.,Butters, T.D.,Williams, S.J.,Davies, G.J. (登録日: 2011-12-21, 公開日: 2012-02-01, 最終更新日: 2023-12-20)

• 主引用文献: Thompson, A.J.,Williams, R.J.,Hakki, Z.,Alonzi, D.S.,Wennekes, T.,Gloster, T.M.,Songsrirote, K.,Thomas-Oates, J.E.,Wrodnigg, T.M.,Spreitz, J.,Stutz, A.E.,Butters, T.D.,Williams, S.J.,Davies, G.J.; Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.; Proc.Natl.Acad.Sci.USA, 109:781-, 2012; PubMed: 22219371; DOI: 10.1073/PNAS.1111482109

実験手法

X-RAY DIFFRACTION (2.09 Å)