4AD2

Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine

Summary for 4AD2

• Entry DOI: 10.2210/pdb4ad2/pdb
• Related: 4ACY 4ACZ 4AD0 4AD1 4AD3 4AD4 4AD5
• Descriptor: GLYCOSYL HYDROLASE FAMILY 71, alpha-D-glucopyranose, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ... (4 entities in total)
• Functional Keywords: hydrolase, endomannosidase, glycoside hydrolase gh99, cazy, enzyme-carbohydrate interaction, mannose glycosidase inhibition
• Biological source: BACTEROIDES XYLANISOLVENS
• Total number of polymer chains: 4
• Total formula weight: 175226.38

Authors

Thompson, A.J.,Williams, R.J.,Hakki, Z.,Alonzi, D.S.,Wennekes, T.,Gloster, T.M.,Songsrirote, K.,Thomas-Oates, J.E.,Wrodnigg, T.M.,Spreitz, J.,Stuetz, A.E.,Butters, T.D.,Williams, S.J.,Davies, G.J. (deposition date: 2011-12-21, release date: 2012-02-01, Last modification date: 2020-07-29)

• Primary citation: Thompson, A.J.,Williams, R.J.,Hakki, Z.,Alonzi, D.S.,Wennekes, T.,Gloster, T.M.,Songsrirote, K.,Thomas-Oates, J.E.,Wrodnigg, T.M.,Spreitz, J.,Stutz, A.E.,Butters, T.D.,Williams, S.J.,Davies, G.J.; Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.; Proc.Natl.Acad.Sci.USA, 109:781-, 2012; PubMed: 22219371; DOI: 10.1073/PNAS.1111482109

Experimental method

X-RAY DIFFRACTION (2.1 Å)