4A9I

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one

Summary for 4A9I

Entry DOI	10.2210/pdb4a9i/pdb
Related	4A9E 4A9F 4A9H 4A9J 4A9K 4A9L 4A9M
Descriptor	BROMODOMAIN CONTAINING 2, 1-[1-(PYRIDIN-2-YL)INDOLIZIN-3-YL]ETHAN-1-ONE, SULFATE ION, ... (5 entities in total)
Functional Keywords	inhibitor, histone, epigenetic reader, signaling protein
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	3
Total formula weight	54788.27
Authors	Chung, C.W.,Bamborough, P. (deposition date: 2011-11-26, release date: 2012-01-11, Last modification date: 2024-05-08)
Primary citation	Chung, C.W.,Dean, A.W.,Woolven, J.M.,Bamborough, P. Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55:576-, 2012 Cited by PubMed: 22136404 DOI: 10.1021/JM201320W PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation