4A9I

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 1187

Chain	Residue
A	TRP97
A	ILE162
A	P9I1185
B	GLN94
B	HOH2088

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P9I A 1185

Chain	Residue
A	ILE162
A	HOH2037
B	EDO1187
A	TRP97
A	VAL103
A	LEU108
A	ASN156

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE P9I B 1188

Chain	Residue
B	TRP97
B	PRO98
B	LEU108
B	ASN156
B	HOH2032

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P9I C 1183

Chain	Residue
A	GLN80
C	TRP97
C	PRO98
C	ASN156
C	ILE162
C	HOH2016

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1184

Chain	Residue
B	ARG100
C	ARG128
C	ASN132
C	TYR134
C	HOH2027
C	HOH2032
C	HOH2049

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1186

Chain	Residue
A	ARG100
A	HOH2012
A	HOH2091

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site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1187

Chain	Residue
A	THR125
A	ARG128
A	ARG129
A	HOH2053
A	HOH2057

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA96-TYR155

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6

Chain	Residue	Details
A	ASP112
C	TYR155
C	ASN156
C	LYS157
A	TYR155
A	ASN156
A	LYS157
B	ASP112
B	TYR155
B	ASN156
B	LYS157
C	ASP112

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20048151, ECO:0007744|PDB:2DVQ, ECO:0007744|PDB:2DVS

Chain	Residue	Details
A	ASP160
A	ASP161
B	ASP160
B	ASP161
C	ASP160
C	ASP161

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