4YN0
Crystal structure of APP E2 domain in complex with DR6 CRD domain
Summary for 4YN0
Entry DOI | 10.2210/pdb4yn0/pdb |
Descriptor | Tumor necrosis factor receptor superfamily member 21, Amyloid beta A4 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | alzheimer, neuron pruning, amyloid precursor protein, apoptosis-cell adhesion complex, apoptosis/cell adhesion |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 48427.18 |
Authors | Xu, K.,Nikolov, D. (deposition date: 2015-03-08, release date: 2015-04-15, Last modification date: 2020-07-29) |
Primary citation | Xu, K.,Olsen, O.,Tzvetkova-Robev, D.,Tessier-Lavigne, M.,Nikolov, D.B. The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation. Genes Dev., 29:785-790, 2015 Cited by PubMed: 25838500DOI: 10.1101/gad.257675.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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