4Y14
Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)
Summary for 4Y14
Entry DOI | 10.2210/pdb4y14/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, CHLORIDE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total) |
Functional Keywords | tyrosine inhibitor complex, hydrolase, protein binding, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 2 |
Total formula weight | 73159.69 |
Authors | Choy, M.S.,Connors, C.,Page, R.,Peti, W. (deposition date: 2015-02-06, release date: 2015-08-05, Last modification date: 2023-09-27) |
Primary citation | Krishnan, N.,Krishnan, K.,Connors, C.R.,Choy, M.S.,Page, R.,Peti, W.,Van Aelst, L.,Shea, S.D.,Tonks, N.K. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125:3163-3177, 2015 Cited by PubMed: 26214522DOI: 10.1172/JCI80323 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.898 Å) |
Structure validation
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