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4X3V

Crystal structure of human ribonucleotide reductase 1 bound to inhibitor

Summary for 4X3V
Entry DOI10.2210/pdb4x3v/pdb
DescriptorRibonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine (3 entities in total)
Functional Keywordscomplex, reducatse, inhibitor, enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight181740.83
Authors
Dealwis, C.G.,Ahmad, M.F.,Alam, I. (deposition date: 2014-12-01, release date: 2015-11-11, Last modification date: 2023-09-27)
Primary citationAhmad, M.F.,Huff, S.E.,Pink, J.,Alam, I.,Zhang, A.,Perry, K.,Harris, M.E.,Misko, T.,Porwal, S.K.,Oleinick, N.L.,Miyagi, M.,Viswanathan, R.,Dealwis, C.G.
Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.
J.Med.Chem., 58:9498-9509, 2015
Cited by
PubMed: 26488902
DOI: 10.1021/acs.jmedchem.5b00929
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.7 Å)
Structure validation

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