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4WVF

Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1

Summary for 4WVF
Entry DOI10.2210/pdb4wvf/pdb
Related4gmx
DescriptorGTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Crm1p, ... (10 entities in total)
Functional Keywordscrm1, inhibitor, sine, kpt, transport protein-transport protein inhibitor complex, transport protein/transport protein inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus: P62826
Cytoplasm: P41920
Total number of polymer chains3
Total formula weight159820.35
Authors
Sun, Q.,Chook, Y. (deposition date: 2014-11-05, release date: 2015-07-15, Last modification date: 2023-12-27)
Primary citationHaines, J.D.,Herbin, O.,de la Hera, B.,Vidaurre, O.G.,Moy, G.A.,Sun, Q.,Fung, H.Y.,Albrecht, S.,Alexandropoulos, K.,McCauley, D.,Chook, Y.M.,Kuhlmann, T.,Kidd, G.J.,Shacham, S.,Casaccia, P.
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat.Neurosci., 18:511-520, 2015
Cited by
PubMed: 25706475
DOI: 10.1038/nn.3953
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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