4WUN
Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom
Summary for 4WUN
Entry DOI | 10.2210/pdb4wun/pdb |
Descriptor | Fibroblast growth factor receptor 1, N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide (3 entities in total) |
Functional Keywords | transferase; transferase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71634.37 |
Authors | Squire, C.J.,Yosaatmadja, C.J. (deposition date: 2014-11-02, release date: 2014-11-19, Last modification date: 2023-09-27) |
Primary citation | Yosaatmadja, Y.,Patterson, A.V.,Smaill, J.B.,Squire, C.J. The 1.65 angstrom resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition. Acta Crystallogr.,Sect.D, 71:525-533, 2015 Cited by PubMed: 25760602DOI: 10.1107/S1399004714027539 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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