4WA7
Crystal Structure of a GDP-bound Q61L Oncogenic Mutant of Human GT- Pase KRas
Summary for 4WA7
Entry DOI | 10.2210/pdb4wa7/pdb |
Related | 4QL3 4TQ9 4TQA |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | small gtpase, signal transduction, gdp binding, gtp binding, hydrolase, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 1 |
Total formula weight | 19781.35 |
Authors | Hunter, J.C.,Manandhar, A.,Gurbani, D.,Chen, Z.,Westover, K.D. (deposition date: 2014-08-28, release date: 2015-06-10, Last modification date: 2023-12-27) |
Primary citation | Hunter, J.C.,Manandhar, A.,Carrasco, M.A.,Gurbani, D.,Gondi, S.,Westover, K.D. Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13:1325-1335, 2015 Cited by PubMed: 26037647DOI: 10.1158/1541-7786.MCR-15-0203 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.986 Å) |
Structure validation
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