4TQ9

Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas

Summary for 4TQ9

• Entry DOI: 10.2210/pdb4tq9/pdb
• Related: 4TQA
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: small gtpase, signal transduction, gdp binding, gtp binding, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 2
• Total formula weight: 39418.43

Authors

Hunter, J.C.,Manandhar, A.,Gurbani, D.,Chen, Z.,Westover, K.D. (deposition date: 2014-06-10, release date: 2015-06-10, Last modification date: 2023-12-27)

• Primary citation: Hunter, J.C.,Manandhar, A.,Carrasco, M.A.,Gurbani, D.,Gondi, S.,Westover, K.D.; Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.; Mol Cancer Res., 13:1325-1335, 2015; PubMed: 26037647; DOI: 10.1158/1541-7786.MCR-15-0203

Experimental method

X-RAY DIFFRACTION (1.491 Å)