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4TQ9

Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues24
Detailsbinding site for residue GDP A 201
ChainResidue
AGLY0
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AMG202
AHOH311
AHOH319
AGLY13
AHOH321
AHOH352
AHOH355
AHOH406
AHOH407
AVAL14
AGLY15
ALYS16
ASER17
AALA18
APHE28
AASP30

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 202
ChainResidue
ASER17
AGDP201
AHOH311
AHOH406
AHOH407
AHOH408

site_idAC3
Number of Residues26
Detailsbinding site for residue GDP B 201
ChainResidue
BGLY0
BGLY13
BVAL14
BGLY15
BLYS16
BSER17
BALA18
BPHE28
BASP30
BGLU49
BASN116
BLYS117
BASP119
BLEU120
BSER145
BALA146
BLYS147
BMG202
BHOH301
BHOH318
BHOH323
BHOH324
BHOH334
BHOH342
BHOH397
BHOH399

site_idAC4
Number of Residues6
Detailsbinding site for residue MG B 202
ChainResidue
BSER17
BGDP201
BHOH318
BHOH397
BHOH399
BHOH401

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140
ChainResidueDetails
AGLY10
AVAL29
AALA59
AASN116
BGLY10
BVAL29
BALA59
BASN116

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17
ChainResidueDetails
ATHR2
BTHR2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
ALYS104
BLYS104

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
ATHR35
BTHR35

226707

PDB entries from 2024-10-30

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